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September 12, 2025Exploration of neuroscienceOpen Access

Tithonia diversifolia (Hemsl.) extract attenuates cognitive dysfunction, oxidative stress and neuroinflammation in a model of sporadic Alzheimer’s disease induced by streptozotocin

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Authors

GGGiovanna de Medeiros GuimarãesCCCamila André CazarinJBJulia Galvan Bernadina

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Overview

Experimental analysis shows Tithonia diversifolia extract reduces neuroinflammation and oxidative stress in Alzheimer's disease, indicating potential therapeutic benefits.

Key Points

  • Tithonia diversifolia extract reversed memory deficits and reduced anxiety in mice with Alzheimer's disease.
  • Behavioral tests demonstrated improvements in depression and cognitive function linked to oxidative stress reduction.
  • Biochemical assays showed less neuroinflammation, increased antioxidant defenses, and partial inhibition of amyloid-beta production.
  • Further research is essential to identify the specific compounds in Tithonia diversifolia responsible for its effects.

Cite This Study

Guimarães et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3f31b076d99fa550c6https://doi.org/10.37349/en.2025.1006109
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer’s disease2024 · 29 citations
  2. 2Roles of Cytokines in Alzheimer’s Disease2024 · 73 citations