What type of study is this?

This is a Experimental Study study.

September 12, 2025APL BioengineeringOpen Access

3D bioprinted human iPSC-derived neural progenitor cells as a novel platform for studying neurogenic niche

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Authors

LMLucas Simões Machado PFPaula Scanavez Ferreira MPMarina Rodrigues Pires

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Overview

Experimental models reveal neurogenic niche development in human neural progenitor cells, suggesting new avenues for drug screening and disease modeling.

Key Points

3D bioprinted neural progenitor cells demonstrated key features of a neurogenic niche, including proliferation and differentiation, for over 110 days.
The constructs formed positive cell clusters expressing neurogenic niche markers such as FABP7, NESTIN, and GFAP within the first 20 days.
The methodology involved using a hydrogel blend to create a 4D model, adding time as a factor to study cellular and molecular features.
This model highlights the potential for studying neurodevelopmental diseases and enhancing drug screening efforts.

Cite This Study

Machado et al. (2025) studied this question.

synapsesocial.com/papers/68d44c3d31b076d99fa558c0 https://doi.org/10.1063/5.0276704

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September 12, 2025APL BioengineeringOpen Access

3D bioprinted human iPSC-derived neural progenitor cells as a novel platform for studying neurogenic niche

View Full Paper

Ask AI

Bookmark

Authors

LMLucas Simões Machado PFPaula Scanavez Ferreira MPMarina Rodrigues Pires

Discussion

Member takes

Overview

Experimental models reveal neurogenic niche development in human neural progenitor cells, suggesting new avenues for drug screening and disease modeling.

Key Points

3D bioprinted neural progenitor cells demonstrated key features of a neurogenic niche, including proliferation and differentiation, for over 110 days.
The constructs formed positive cell clusters expressing neurogenic niche markers such as FABP7, NESTIN, and GFAP within the first 20 days.
The methodology involved using a hydrogel blend to create a 4D model, adding time as a factor to study cellular and molecular features.
This model highlights the potential for studying neurodevelopmental diseases and enhancing drug screening efforts.

Cite This Study

Machado et al. (2025) studied this question.

synapsesocial.com/papers/68d44c3d31b076d99fa558c0 https://doi.org/10.1063/5.0276704

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