Cross-sectional study identifies gut microbiota dysbiosis and altered diversity in NAFLD patients, suggesting potential disease involvement.
The association between gut microbiota dysbiosis and non-alcoholic fatty liver disease (NAFLD) in 132 adults were diagnosed using ultrasonography. Stool samples were analyzed using 16S rRNA sequencing to assess microbiota composition. Patients with NAFLD showed a significant decrease in Bacteroidetes and an increase in Firmicutes and Proteobacteria compared to controls. Altered microbial diversity correlated with elevated liver enzymes and insulin resistance markers. Data shows that gut microbiota imbalance plays a contributory role in the pathogenesis of NAFLD.
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Singh et al. (2025) studied this question.
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