To Evaluate and Compare the Effectiveness of Topical Amlexanox, Curcuma Longa Extract, and Clobetasol Propionate in the Treatment of Oral Lichen Planus: An Original Research

Background: Lichen planus is a chronic autoimmune inflammatory mucocutaneous disease affecting the skin and oral mucosa. Objectives: The objectives of the study were to evaluate and compare the effectiveness of topical Amlexanox, Curcuma longa extract, and clobetasol propionate in the treatment of oral lichen planus (OLP). Materials and Methods: A total of 45 patients with OLP were randomly divided into three groups: Group I (Amlexanox), Group II (Curcuma longa extract), and Group III (Clobetasol propionate). Baseline recordings of pain and burning sensation were conducted using the visual analog scale (VAS) and numeric rating scale (NRS). Clinical signs of erythema, ulceration, and lesion size were evaluated and recorded. All patients were evaluated at weekly intervals during the 2-month therapy period, as well as during follow-up for 3 months (at 15-day intervals). Results: Amlexanox showed a significant reduction in pain and burning sensation, along with a decrease in clinical signs of OLP. However, complete remission was not achieved, and mild reappearance of erythema was observed. Curcuma longa extract also showed a significant reduction in pain and burning sensation, with a considerable reduction in clinical signs to a tolerable level. This reduction remained static during the follow-up period. Clobetasol propionate demonstrated higher efficacy in reducing pain, burning sensation, and clinical signs of OLP. Although complete remission was achieved during the therapy period, the reappearance of pain, burning sensation, and clinical signs was noted during follow-up visits. Conclusion: Amlexanox and Curcuma longa extract reduce the signs and symptoms of OLP to a tolerable level, with improvement remaining static after the cessation of therapy. Clobetasol propionate causes complete remission of signs and symptoms of OLP, but there is a higher chance of recurrence.