Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 12, 2025Frontiers in GeneticsOpen Access

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition

View Full Paper
Ask AI
Bookmark
Share

Authors

GÖGizem ÖnderÖÖÖzkan ÖzdemirFTFulya Taylan

Discussion

Loading...

Member takes

Overview

Germline variant analysis reveals cancer predisposition in pediatric leukemia/lymphoma cases, suggesting clinical utility.

Key Points

  • Clinical utility of germline testing showed significant findings in childhood cancers, highlighting risks.
  • Thirteen relevant germline variants were identified in cancer predisposition genes like TP53 and BRCA1.
  • Germline sequencing in a Turkish cohort provided insights into familial cancer syndromes and medical decision-making.
  • Findings stress the importance of genetic counseling for families, especially in areas with high consanguinity.

Cite This Study

Önder et al. (2025) studied this question.

synapsesocial.com/papers/68d44c4d31b076d99fa55e81https://doi.org/10.3389/fgene.2025.1624306
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1JAK/STAT blockade reverses the malignant phenotype of Hodgkin and Reed-Sternberg cells2022 · 9 citations
  2. 2Perception and management of cancer predisposition in pediatric cancer centers: A European‐wide questionnaire‐based survey2023 · 2 citations
  3. 3Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells2023 · 8 citations
  4. 4Nordic Guidelines for Germline Predisposition to Myeloid Neoplasms in Adults: Recommendations for Genetic Diagnosis, Clinical Management and Follow-up2019 · 96 citations
  5. 5<b>Germline Cancer Predisposition Variants in</b> <b>Pediatric Rhabdomyosarcoma: A Report From the Children’s Oncology Group</b>2020 · 113 citations