Growth factors and osseointegration in dental implants - A review

Osseointegration is essential for the long-term success of dental implants. However, achieving consistent and rapid integration remains challenging. Growth factors like PDGF, BMPs, TGF-β, IGF, VEGF, PRP and PRF have shown potential to enhance bone healing and implant stability. These agents promote osteoblast activity, angiogenesis and matrix formation, accelerating peri-implant bone regeneration. Delivery methods such as platelet concentrates, surface coatings and biomaterial integration have demonstrated promising outcomes. Therefore, it is of interest to review summarizing the biological rationale, clinical evidence, application techniques and future prospects of growth factor use in implant dentistry.