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This is a Animal Study study (also classified as: In Vitro Study, Quantitative Study).

September 12, 2025Phytotherapy Research

Artesunate Enhances DUSP1‐Dependent Mitochondrial Integrity to Mitigate Renal Fibrosis in Diabetic Kidney Disease

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Artesunate treatment restored mitochondrial structure, reduced fibrotic markers, and suppressed inflammation.
Notably, DUSP1 expression was significantly reduced in DKD patients, correlating with greater fibrosis.
In vitro, artesunate reversed high-glucose–induced mitochondrial dysfunction and fibrotic signaling.
DUSP1 overexpression mimicked artesunate's therapeutic actions, indicating its role in fibrosis mitigation.

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Implication

Observational analysis finds artesunate improves mitochondrial integrity and reduces fibrosis in diabetic kidney disease, highlighting potential therapeutic implications.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d44c5531b076d99fa56090 https://doi.org/10.1002/ptr.70091

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Implication

Observational analysis finds artesunate improves mitochondrial integrity and reduces fibrosis in diabetic kidney disease, highlighting potential therapeutic implications.

Artesunate Enhances DUSP1‐Dependent Mitochondrial Integrity to Mitigate Renal Fibrosis in Diabetic Kidney Disease

Key Points

Discussion

Implication

Cite This Study

Artesunate Enhances DUSP1‐Dependent Mitochondrial Integrity to Mitigate Renal Fibrosis in Diabetic Kidney Disease

Key Points

Discussion

Implication

Cite This Study

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