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September 12, 2025Experimental PhysiologyOpen Access

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

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Combined ginsenoside-MC1 and irisin therapy reduces mitochondrial apoptosis in diabetic rats, suggesting new treatment for hepatic injury.

Combined ginsenoside-MC1 and irisin therapy lowered liver injury markers in diabetic rats.
Significant reductions in ALT and AST levels were observed, enhancing liver function.
The approach involved assessing mitochondrial function and apoptotic markers via western blotting.
This therapy may offer a new protective strategy against liver damage in diabetic patients.

Lin et al. (2025) studied this question.

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Combined ginsenoside-MC1 and irisin therapy reduces mitochondrial apoptosis in diabetic rats, suggesting new treatment for hepatic injury.