Genetic and Developmental Insights into Dental Anomalies in Cleft Lip and Palate

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Dental anomalies in cleft lip and palate include hypodontia, occurring in 28 to 79% of patients.
Hyperdontia is found in up to 73% of cleft lip and palate cases, with over 90% having enamel defects.
The genetic basis involves MSX1-PAX9 and others, crucial in linking cleft formation and tooth development.
Early intervention is vital due to high prevalence of anomalies impacting rehabilitation and quality of life.

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Narrative review highlights dental anomalies linked to cleft lip and palate, suggesting genetic and developmental connections.

Rashid et al. (2025) studied this question.

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