Novedosos agentes dopaminérgicos y serotoninérgicos derivados del quinolin-metiladamantano y amino-metiladamantano. Síntesis y perfil farmacológico.

Serotonin (5-HT) and dopamine (DA) are key neurotransmitters in the central nervous system (CNS) that are involved in the regulation of behav-ior. Dysfunction of dopaminergic and serotonergic neurotransmitter pathways, which are responsible for the regulation of mood, cognition, and movement, can lead to a wide range of brain disorders, both neurological and psychiatric. DA is implicated in various neurodegenerative and neuropsychiatric diseases, and dopaminergic systems in the brain are known to receive serotonergic in-nervation. In the present study, we present the synthesis and preliminary phar-macological evaluation of the compounds N-[(2-chloro-quinolin-3-yl) methyl]-methyladamantane (7) and amino-methyladamantane (10), which were found to have dopaminergic and serotonergic activities in the central nervous system. The strategy used in the design of hybrid compound 7 led to the development of a novel agent with antipsychotic and/or anxiolytic activity. Compound 10 only showed antiparkinsonian activity. These compounds contribute to the pharma-cological arsenal for the treatment of pathologies related to neurodegenerative and neuropsychiatric disorders.