September 12, 2025PharmaceuticalsOpen Access

Genetic Basis of Non-Syndromic Childhood Glaucoma Associated with Anterior Segment Dysgenesis: A Narrative Review

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Discussion

Narrative review highlights genetic causes of childhood glaucoma and emerging molecular therapies.

Twenty causative genes linked to non-syndromic childhood glaucoma have been identified, with FOXC1 and PAX6 being the most prominent.
The increase in genetic testing has clarified the phenotypic overlap among genetic causes of glaucoma, especially concerning PAX6 and aniridia cases.
Molecular therapies, including CRISPR-Cas9, have shown promise in treating glaucoma, particularly in mouse models.
Gene delivery using adeno-associated viral vectors is the most common method, improving outcomes for retinal ganglion cells.

Cronbach et al. (2025) studied this question.

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