September 12, 2025Open Access

Assessment of Circulating Cell-free Mitochondrial DNA as a damage- associated Molecular Pattern in Predicting Severity and Mortality of Sepsis and septic shock patients

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Elevated cell-free mitochondrial DNA is linked to higher mortality rates in patients with sepsis and septic shock.
Participants showed significant correlations between cell-free mitochondrial DNA levels and clinical markers like CRP and SOFA scores.
The study identified cell-free mitochondrial DNA as a promising tool for predicting 28-day mortality, achieving AUC of 0.865.
Cell-free mitochondrial DNA levels were significantly higher in non-survivors, emphasizing its relevance in clinical management.

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Implication

Prospective study reveals elevated cell-free mitochondrial DNA levels predict mortality in sepsis, indicating its role as a damage-associated molecular pattern.

Cite This Study

Bushra et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7331b076d99fa56b46 https://doi.org/10.21203/rs.3.rs-7469131/v1

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Implication

Prospective study reveals elevated cell-free mitochondrial DNA levels predict mortality in sepsis, indicating its role as a damage-associated molecular pattern.

Assessment of Circulating Cell-free Mitochondrial DNA as a damage- associated Molecular Pattern in Predicting Severity and Mortality of Sepsis and septic shock patients

Key Points

Discussion

Implication

Cite This Study

Assessment of Circulating Cell-free Mitochondrial DNA as a damage- associated Molecular Pattern in Predicting Severity and Mortality of Sepsis and septic shock patients

Key Points

Discussion

Implication

Cite This Study

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