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This is a Experimental Study study.

September 16, 2025Open Access

Layer-specific glutamatergic inputs and Parvalbumin interneurons modulate early life stress induced alterations in prefrontal glutamate release during fear conditioning in pre-adolescent rats

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Authors

JSJiamin SongTongji University MYMuhammad Usman YounusUniversité Toulouse III - Paul Sabatier HLHong LongSalk Institute for Biological Studies

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Implication

Research demonstrates altered glutamate release in the prefrontal cortex during fear conditioning in rats, suggesting early life stress impacts emotional regulation.

Key Points

Altered glutamate release was observed during fear conditioning in pre-adolescent males exposed to early life stress.
Presynaptic glutamate release probability changed in different layers of the prefrontal cortex, affecting male rats specifically.
Increased activation of Parvalbumin interneurons was noted in layer V, highlighting layer-specific impacts of early life stress.
Findings suggest that early life stress modifies neurotransmitter dynamics during crucial developmental stages, affecting future emotional health.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7b31b076d99fa56d7a https://doi.org/10.1101/2025.09.08.674892

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Implication

Research demonstrates altered glutamate release in the prefrontal cortex during fear conditioning in rats, suggesting early life stress impacts emotional regulation.

Layer-specific glutamatergic inputs and Parvalbumin interneurons modulate early life stress induced alterations in prefrontal glutamate release during fear conditioning in pre-adolescent rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Layer-specific glutamatergic inputs and Parvalbumin interneurons modulate early life stress induced alterations in prefrontal glutamate release during fear conditioning in pre-adolescent rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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