Supplementary Figure S3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895

Q: What type of study is this?

This is a Quantitative Study study.

Jack C. Stromatt; Eman Ahmed; Thomas Drabison; Mahesh R. Nepal; Anika T. Chowdhury; Shelley Orwick; Daelynn R. Buelow; Eric D. Eisenmann; Kevin M. Huang; Alex Sparreboom; Sharyn D. Baker

doi:10.1158/2767-9764.30111359

September 12, 2025Open Access

Supplementary Figure S3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895

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Key Points

TL-895 plasma concentrations were measured in C57BL/6 and NSG mice, significantly contributing to understanding drug interactions.
Data showed a mean plasma concentration measured after an oral dose of either 3 or 10 mg/kg across both mouse strains.
This analysis involved male and female mice, with data representing five animals per group to ensure reliability.
Findings highlight the importance of assessing pharmacokinetic profiles in different genetic backgrounds to evaluate drug effects.

Implication

Analysis shows plasma concentrations of TL-895 in C57BL/6 and NSG mice, indicating drug-drug interactions.

Abstract

Pharmacokinetic profile of TL-895 in C57BL/6 and NSG mice. TL-895 plasma concentrations were determined in male and female mice on a C57BL/6 (A) or NSG (B) background strain. Mice received a single oral dose of 3 or 10 mg/kg. Data represent mean values (symbols) and SD (error bars) using 5 animals per group.

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Cite This Study

Stromatt et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7b31b076d99fa56d9e https://doi.org/10.1158/2767-9764.30111359

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Supplementary Figure S3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895

Key Points

Implication

Abstract

Discussion

Cite This Study

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