Competitive inhibitors of aldehyde dehydrogenase 1A1 show high affinity and cellular compatibility, suggesting new screening methods.
We report the first competitive aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor featuring a fluorogenic binding response and nanomolar affinity (KD), enabling real-time screening of non-fluorescent inhibitors with high cellular compatibility and no observed toxicity.
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Ghosh et al. (2025) studied this question.
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