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September 16, 2025The Journal of PhysiologyOpen Access

Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2‐adrenergic signalling

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Randomized trial shows clenbuterol increases lean mass in healthy men, but reduces cardiorespiratory fitness, indicating potential risks.

Clenbuterol effectively induced a lean mass gain of 0.91 kg while showing no effect on fat mass.
Participants experienced a significant 7% reduction in maximal oxygen uptake, highlighting adverse impacts on fitness.
Clenbuterol increased muscle protein content and β2-adrenergic signalling activation, yet tolerance develops during use.
The findings reveal a duality of clenbuterol's effects, promoting muscle accretion while negatively influencing cardiovascular health.

Hostrup et al. (2025) studied this question.

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