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September 16, 2025World PsychiatryOpen Access

A pragmatic randomized controlled trial of cognitive therapy for post‐traumatic stress disorder in children and adolescents exposed to multiple traumatic stressors: the DECRYPT trial

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Pragmatic RCT evaluates cognitive therapy impact on PTSD in youth, suggesting improvements over treatment-as-usual.

CT-PTSD showed superior effectiveness to TAU in reducing PTSD symptoms at 11 months post-treatment.
The primary outcome was assessed using the CRIES-8 score, showing substantial improvement in emotional difficulties.
Youth aged 8-17 with multiple trauma exposure were enrolled for the trial comparing CT-PTSD with TAU.
This study supports integrating CT-PTSD within standard psychological treatment for youth with complex PTSD.

Meiser‐Stedman et al. (2025) studied this question.

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