Synthesis reveals novel indolo-pyrimidine derivatives showing moderate anticancer activity against multiple cell lines, suggesting promising drug development potential.
The synthesis of novel indolo-pyrimidine derivatives is of considerable interest due to the combined pharmacological benefits of indole and pyrimidine cores, particularly for anticancer applications. In this study, we report an efficient three-step synthesis of a novel series of 3-amino-1-(2-amino-6-chloropyrimidin-4-yl)-1H-indole-2-carboxylate derivatives, employing specific bases and solvents, in high yields. The synthetic route proceeds through key intermediates—2-aminopyrimidine-benzonitrile and 2-aminopyrimidine-glycinate culminating in the formation of 2-aminopyrimidine-indole hybrids. Biological evaluation against three human cancer cell lines and one normal cell line demonstrated moderate anticancer activity and minimal toxicity, highlighting their potential as promising leads for further anticancer drug development.
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Pranathi et al. (2025) studied this question.
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