Protein condensates induce biopolymer filament bundling and network remodeling via capillary interactions

Carolyn A. Feigeles; Artis Brasovs; Adam Puchalski; Olivia Laukat; Konstantin G. Kornev; Kimberly L. Weirich

doi:10.1039/d5sm00508f

January 1, 2025Soft MatterOpen Access

Protein condensates induce biopolymer filament bundling and network remodeling via capillary interactions

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Key Points

Protein condensates stimulate bundling of biopolymer filaments, enhancing structural organization for cellular functions.
The actin cytoskeleton’s mechanical structure is significantly influenced by capillary interactions among protein condensates.
Analysis of protein interactions reveals critical pathways for network remodeling in cellular processes overall.
These findings highlight the potential for targeting protein interactions in therapies for cytoskeletal-related diseases.

Implication

Observational analysis shows protein condensates affect biopolymer structures in cells, suggesting new insights into cytoskeletal dynamics.

Abstract

Many cellular processes are regulated by biopolymers that are self-assembled into higher order structures by protein interactions. The actin cytoskeleton, which forms the mechanical structure of cells, consists of actin...

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Cite This Study

Feigeles et al. (2025) studied this question.

synapsesocial.com/papers/68d4506b31b076d99fa576f4 https://doi.org/10.1039/d5sm00508f

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Protein condensates induce biopolymer filament bundling and network remodeling via capillary interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

Protein condensates induce biopolymer filament bundling and network remodeling via capillary interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

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