Advancing Radiogenomics: MRI-Guided Identification of Novel Breast Cancer Molecular Subtypes

Motivation: Current radiogenomics studies are limited in linking image phenotypes with genomic phenotypes, and their clinical translation value remains inadequately explored. Goal(s): Define novel breast cancer subtype using only image-associated genes and evaluate its prognostic and therapeutic importance. Approach: Extract a comprehensive image profile, identify image-associated genes, and define an image-inspired genomic subtype (I2G-C). Results: The new subtype, I2G-C, is distinct from traditional subtypes, characterized by unique immune and repair functions. I2G-C shows significant predictive value for patients receiving anti-HER2 therapies and identifies high-risk patients in terms of disease-free survival. Impact: This study advances radiogenomics by demonstrating functional MRI-guided identification of new breast cancer subtypes, highlighting its potential in clinical applications.