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September 16, 2025Journal of Vascular DiseasesOpen Access

Acute Aortic Occlusion Causing Bilateral Lower Extremity Ischemia That Resolved with tPA Administration

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Case report details systemic thrombolysis resolving ischemia in a patient with acute aortic occlusion, suggesting clinical implications.

Systemic thrombolysis using tPA restored blood flow in a patient with acute aortic occlusion.
The patient showed marked symptom improvement after one hour post-tPA administration, verified by Doppler.
Despite complications, including retroperitoneal bleeding, the patient regained full function by discharge.
This case highlights the potential of tPA in remote settings lacking urgent vascular intervention capabilities.

Gallagher et al. (2025) studied this question.

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