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September 16, 2025European PsychiatryOpen Access

Echoes of solitude: systematic review and meta-analysis revealing mortality risks in older adults due to loneliness, social isolation, and living alone

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Authors

ANA. NakouEDElena DragiotiΝΖΝεκταρία Ζαγοριανάκου

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Overview

Meta-analysis reveals significant impacts of loneliness and social isolation on mortality in older adults, highlighting urgent public health needs.

Key Points

  • Loneliness, social isolation, and living alone were associated with increased mortality risks among older adults.
  • Meta-analysis found loneliness increased all-cause mortality risk by 14%, social isolation by 35%, and living alone by 21%.
  • Cohort studies utilized robust methodologies, including random-effects models to analyze data on 86 qualifying studies.
  • Public health interventions are critical to address loneliness and social isolation, particularly given the observed heterogeneity in study outcomes.

Cite This Study

Nakou et al. (2025) studied this question.

synapsesocial.com/papers/68d4507331b076d99fa57b69https://doi.org/10.1192/j.eurpsy.2025.1746
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Loneliness, Social Isolation, and Living Alone Associations With Mortality Risk in Individuals Living With Cardiovascular Disease: A Systematic Review, Meta-Analysis, and Meta-Regression2022 · 39 citations
  2. 2Loneliness and Social Isolation as Risk Factors for Mortality2015 · 6,133 citations
  3. 3Social isolation, regardless of living alone, is associated with mortality: the Otassha study2024 · 16 citations
  4. 4Social isolation as a risk factor for all-cause mortality: Systematic review and meta-analysis of cohort studies2023 · 116 citations
  5. 5Contribution of risk factors to excess mortality in isolated and lonely individuals: an analysis of data from the UK Biobank cohort study2017 · 436 citations