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September 16, 2025European PsychiatryOpen Access

Age at menarche and its implications for the mood-psychosis continuum

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Authors

MPM. PurićEES Research (United Kingdom)MNMilkica NešićUniversity of NisMGMarta GostiljacEES Research (United Kingdom)

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Implication

Observational analysis finds correlation between age at menarche and symptom severity in bipolar disorder and schizophrenia, suggesting hormonal links.

Key Points

  • Age at menarche correlates with the severity of symptoms in bipolar disorder and schizophrenia.
  • Correlation coefficient between age at menarche and SBS score is r=0.257, p=0.028.
  • Assessment used included the Schizo-Bipolar Scale and the Brief Psychiatric Rating Scale.
  • Highlights the potential link between hormonal changes and mental health outcomes, needing further research.

Cite This Study

Purić et al. (2025) studied this question.

synapsesocial.com/papers/68d4507331b076d99fa57b71https://doi.org/10.1192/j.eurpsy.2025.1076
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of early menarche on increased anxiety levels in female patients2025
  2. 2Impact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study2025 · 4 citations
  3. 3Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study2024 · 28 citations
  4. 4Modern Determinants of Earlier Menarche and Mental Health: A Translational Review for Clinicians2026
  5. 5Association between age of menarche and suicidality: A systematic review and meta-analysis2026