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September 16, 2025European PsychiatryOpen Access

Long-term prognosis of schizophrenia in a Danish context

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Authors

HHHelene Gjervig HansenCopenhagen University HospitalMSMarie StarzerUniversity of Copenhagen

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Implication

Observational analysis found 40% in symptom remission after Early Intervention Services, indicating challenges in managing negative symptoms.

Key Points

  • A significant 40% of participants achieved symptom remission after 20 years, yet many faced chronic negative symptoms.
  • The OPUS trial followed 578 individuals, with only 17% reaching clinical recovery despite periods of treatment.
  • Longitudinal data revealed that 29% remained on antipsychotic medication after two decades, showing long-term treatment patterns.
  • The study highlights suicide as a major concern, contributing to a mortality rate of 14.2 among participants over 20 years.

Cite This Study

Hansen et al. (2025) studied this question.

synapsesocial.com/papers/68d4507931b076d99fa57c64https://doi.org/10.1192/j.eurpsy.2025.132
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical illness course and family-related outcomes among parents with a first episode of schizophrenia spectrum disorder: a 20-year follow-up of the OPUS trial2024 · 3 citations
  2. 2Real-world effectiveness of antipsychotic treatment of functional outcomes over 10 years: A national cohort of patients in Denmark with schizophrenia2026
  3. 3Long-Term Outcomes in First-Episode Psychosis: Insights from a 20-Year Cohort Study to Inform Recovery-Oriented Care Models2025
  4. 4Long-term antipsychotic use and its association with outcomes in schizophrenia – the Northern Finland Birth Cohort 19662016 · 26 citations
  5. 5Recovery in schizophrenia: the role of antipsychotic treatment2024