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September 16, 2025European PsychiatryOpen Access

Sleep Deprivation’s Effect on Circadian Genes Expression and Its Associtations with Depression Symtoms and Psychomotor Abilities

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Observational analysis shows sleep deprivation affects circadian genes in 72 participants, suggesting links to mood and psychomotor abilities.

Reduced expression of CLOCK, BMAL1, CRY1, PER1, and NR1D1 is linked to impaired psychomotor functions after sleep deprivation.
Negative correlations were found between motor function errors and all examined circadian genes in non-respondents to depression symptoms.
Increased NPAS2 expression in respondents showed a different impact, indicating varied effects of sleep deprivation on mood.
Findings highlight the need for more research on circadian system genes and their roles in cognitive function and mood regulation.

Witkowska et al. (2025) studied this question.

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Observational analysis shows sleep deprivation affects circadian genes in 72 participants, suggesting links to mood and psychomotor abilities.