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September 16, 2025European PsychiatryOpen Access

Enhancing Lithium Monitoring: A Comparative Analysis of Saliva, Erythrocyte, and Plasma Levels in Psychiatric Patients

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Authors

DVDušan VlahovićDKDalibor KarlovićVPVjekoslav Peitl

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Overview

This analysis finds significant correlation between lithium levels in saliva and plasma, suggesting potential for effective monitoring in patients with bipolar disorder.

Key Points

  • Saliva levels of lithium significantly correlate with plasma levels, indicating a potential alternative monitoring method.
  • Linear regression analysis shows a significant correlation (p<0.01) between saliva and plasma lithium levels among psychiatric patients.
  • Erythrocyte lithium levels did not significantly correlate with either saliva or plasma levels, pointing to the uniqueness of salivary monitoring.
  • Using non-invasive saliva testing could enhance treatment options for mood disorder patients, improving safety and adherence.

Cite This Study

Vlahović et al. (2025) studied this question.

synapsesocial.com/papers/68d4508231b076d99fa581d5https://doi.org/10.1192/j.eurpsy.2025.1094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rethinking Lithium Monitoring: Insights from a Comparative Analysis of Saliva, Plasma, and Erythrocytes2025
  2. 2Lithium Across Saliva, Plasma, and Erythrocytes and Its Links to Electrolytes/ Renal Markers in the First Treatment Week2025
  3. 3Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review2024
  4. 4Therapeutic Drug Monitoring and Safety Considerations of Lithium Therapy in Mood Disorder2026
  5. 5Acceptability and accuracy of point-of-care monitoring of lithium levels2026