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September 16, 2025Forum of Clinical OncologyOpen Access

Brain metastases in non-small cell lung cancer: Prevalence, high-risk factors, and overall survival prognosis

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Retrospective study finds brain metastases prevalent in 13.1% of NSCLC patients, suggesting key risk factors.

The prevalence of brain metastases in non-small cell lung cancer is 13.1% at diagnosis, affecting patient outcomes.
Patients with brain metastases had a median overall survival of 15.3 months, significantly lower than 18.3 months for those without.
Non-squamous carcinoma and high serum CEA levels were identified as key risk factors for developing brain metastases.
EGFR/ALK gene mutation status correlated with better overall survival outcomes for patients with brain metastases.

Ngo et al. (2025) studied this question.

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