Synthesis of new derivatives metochloro bromide drugs from 3-carboxy indole and evaluation of some their biological activities

The discovery of new 2-Carboxy indole-based molecules with strong antibacterial properties remains a major emphasis in medicinal chemistry. In this study, a number of hybrid compounds (B1-B8) were created by functionalizing 2- Carboxy indole derivatives with a variety of heterocyclic frameworks such as benzothiazole and substituted aromatic groups. The synthesis process included several steps, including the manufacture of indole-3-carbonyl chloride, and condensation with potassium salts to produce gibberellin derivatives. The synthesized compounds were structurally confirmed using M.P (TLC), FT-IR, and NMR (1H and 13C) spectroscopy. This study synthesized and characterized new indole-based derivatives using FT-IR and NMR methods. Several compounds demonstrated strong antibacterial and antifungal action, with compound B3 being the most effective. The structure-activity connection research found that electron-withdrawing groups increased activity, while bulky or electron-donating groups decreased it.