Methylquinolinium-Enhanced Near-Infrared Hemicyanine Dye for Ratiometric NAD(P)H Sensing in Live Cells via Carbon-Carbon Bond Conjugation

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This is a Experimental Study study.

Sushil K. Dwivedi; Adonis Amoli; Mahmood Norouzi; Alicia Guo; Henry Lanquaye; Tyler Gregersen; Yan Zhang; Micaela Geborkoff; Athar Ata; Thomas Werner; Haiying Liu

doi:10.1039/d5tb00610d

January 1, 2025Journal of Materials Chemistry B

Methylquinolinium-Enhanced Near-Infrared Hemicyanine Dye for Ratiometric NAD(P)H Sensing in Live Cells via Carbon-Carbon Bond Conjugation

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Key Points

The sensor demonstrates high sensitivity for nadh detection in live cells.
Utilizing a methylquinolinium acceptor, the sensor showcases improved specificity.
Carbon-carbon bond conjugation enhances the performance of the hemicyanine dye.
This technology could enable advancements in live-cell imaging and monitoring.

Implication

Ratiometric sensor detects nadh in living cells, highlighting its potential for real-time monitoring.

Abstract

We introduce a ratiometric sensor designed for sensitive and specific detection of NAD(P)H in living cells, tissues, and whole organisms. The sensor incorporates a methylquinolinium acceptor linked to a near-infrared...

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Cite This Study

Dwivedi et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa5876d https://doi.org/10.1039/d5tb00610d

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Methylquinolinium-Enhanced Near-Infrared Hemicyanine Dye for Ratiometric NAD(P)H Sensing in Live Cells via Carbon-Carbon Bond Conjugation

Key Points

Implication

Abstract

Discussion

Cite This Study

Methylquinolinium-Enhanced Near-Infrared Hemicyanine Dye for Ratiometric NAD(P)H Sensing in Live Cells via Carbon-Carbon Bond Conjugation

Key Points

Implication

Abstract

Discussion

Cite This Study

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