Illustrative diagram depicts gene fusion events in NUT carcinoma, suggesting pathways for oncogenic transcription.
Supplementary Figure S6: Schematic of an example gene fusion event leading to NUT carcinoma pathogenesis. Diagram illustrating the fusion of the BRD4 and NUTM1 genes following chromosomal rearrangement. The NUTM1 fusion protein drives oncogenic transcription through upregulation of target genes such as MYC, SOX2, and p63.
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Kim et al. (2025) studied this question.
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