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September 15, 2025

Figure S15 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer

Nikola Knoll Sarah Masser Blanka Bordas Richard Y. Ebright Guangyan Li Devishi Kesar Eliana Destefanis Nicholas Kania Diego J. Rodriguez Jayu Jen Sydney E. Zagar Caleb Mensah Zixin Chen Samuel J. Moffitt Erhumuoghene M. Enakireru Yao He Baomou Feng Mira K. Chokshi Cyrus Y. Jin Srivatsan Raghavan William R. Sellers Kathleen M. Mulvaney

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Key Points

Treatment with MTAC-PRMT5i shows differential mRNA expression in glioblastoma cells, indicating a potential effective therapy.
GSEA analysis of A172 cells reveals notable changes in mRNA levels when treated with MTAC-PRMT5i compared to control.
Observational analysis of mRNA expression in CDKN2A/MTAP null glioblastoma cells supports the effectiveness of combinatorial drug treatments.
These findings highlight the need for further investigation into combination therapies for cancers with MTAP deletions.

Abstract

Figure S15. Differential mRNA GSEA expression of A172 CDKN2A/MTAP null glioblastoma cells treated with MTAC-PRMT5i compared to control.

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Cite This Study

Knoll et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588cb https://doi.org/10.1158/0008-5472.30125763

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S16 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
2Figure S17 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
3Figure S12 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
4Figure S5 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
5Figure S10 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025

Figure S1 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S13 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S3 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025