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September 15, 2025

Figure S13 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer

Nikola Knoll Sarah Masser Blanka Bordas Richard Y. Ebright Guangyan Li Devishi Kesar Eliana Destefanis Nicholas Kania Diego J. Rodriguez Jayu Jen Sydney E. Zagar Caleb Mensah Zixin Chen Samuel J. Moffitt Erhumuoghene M. Enakireru Yao He Baomou Feng Mira K. Chokshi Cyrus Y. Jin Srivatsan Raghavan William R. Sellers Kathleen M. Mulvaney

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Key Points

Increased KRAS signaling was observed with treatments including ERK1/2i and A/B/C-RAFi in MTAP-deleted cancer.
Differential mRNA GSEA pathway analysis highlighted the significance of KRAS signaling in these treatment combinations.
These findings suggest that combining treatments may enhance therapeutic effectiveness in MTAP-deleted cancer.
Further exploration of KRAS signaling pathways could lead to improved treatment strategies for this cancer type.

Implication

Analysis shows KRAS signaling increased in cancer treatments with ERK1/2i and A/B/C-RAFi, indicating potential pathways.

Abstract

Figure S13. Differential mRNA GSEA pathway analysis shows KRAS SIGNALING UP in ERK1/2i and A/B/C-RAFi treatment.

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Cite This Study

Knoll et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588c1 https://doi.org/10.1158/0008-5472.30125769

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S16 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
2Figure S12 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
3Figure S14 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
4Figure S6 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
5Figure S18 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025

Figure S10 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S15 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S19 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025