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September 15, 2025

Figure S14 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer

Nikola Knoll Sarah Masser Blanka Bordas Richard Y. Ebright Guangyan Li Devishi Kesar Eliana Destefanis Nicholas Kania Diego J. Rodriguez Jayu Jen Sydney E. Zagar Caleb Mensah Zixin Chen Samuel J. Moffitt Erhumuoghene M. Enakireru Yao He Baomou Feng Mira K. Chokshi Cyrus Y. Jin Srivatsan Raghavan William R. Sellers Kathleen M. Mulvaney

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Key Points

Identifying effective combination treatments significantly improves outcomes in MTAP-deleted cancer cases.
PCR analysis shows distinct gene expression profiles in RAS-MAPK active compared to wildtype cells.
This research leverages CRISPR technology to enhance drug screening efficiency in cancer therapy.
Findings could guide future therapeutic strategies targeting RAS pathways in MTAP-deleted cancers.

Implication

Combinatorial screening reveals effective treatments for MTAP-deleted cancer, highlighting RAS-MAPK pathways.

Abstract

Figure S14. qRT-PCR of RAS target genes in RAS-MAPK active and RAS-MAPK wildtype cells.

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Cite This Study

Knoll et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588cf https://doi.org/10.1158/0008-5472.30125766

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S18 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
2Figure S13 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
3Figure S10 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
4Figure S6 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
5Figure S5 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025

Figure S19 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S3 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S17 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025