Figure S8 from Transcriptome Analysis of Matched Cohorts of Long- and Short-term Survivors in Advanced High-grade Serous Tubo-ovarian Cancer

Q: What type of study is this?

This is a Quantitative Study study.

Sofya Marchenko; Niklas Goernitz; Wiebke A. Zoern; Maria Joosten; Inga Hoffmann; Jalid Sehouli; Gerald Niedobitek; Carsten Denkert; Bruno V. Sinn; Svenja Kolb; José Carbonell‐Caballero; Alfonso Valencia; Mihnea P. Dragomir; Wolfgang Schmitt; David Horst; Elena Ioana Braicu; Christine Sers; Jonathan Pohl; Eliane T. Taube

doi:10.1158/1078-0432.30125589

Key Points

The analysis shows significant enrichment of a 101-gene signature in advanced high-grade serous tubo-ovarian cancer.
GSEA for Millstein sub-signatures indicates that only the complete gene signature had significant results.
Incremental increases in gene sets used in analysis provide insights into gene signature effectiveness.
Findings indicate that the transcriptome analysis may help identify potential biomarkers in cancer.

Implication

GSEA reveals significant enrichment of a 101-gene signature in patients with advanced high-grade serous tubo-ovarian cancer, suggesting potential biomarkers.

Abstract

Figure S8 depicts GSEA for Millstein sub-signatures in the Charité cohort. Gene sets were incrementally increased by one gene at thetime (see color code). X-axis shows the NES and only the full 101-gene signature was significantly enriched.

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Cite This Study

Marchenko et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa58909 https://doi.org/10.1158/1078-0432.30125589

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Figure S8 from Transcriptome Analysis of Matched Cohorts of Long- and Short-term Survivors in Advanced High-grade Serous Tubo-ovarian Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S8 from Transcriptome Analysis of Matched Cohorts of Long- and Short-term Survivors in Advanced High-grade Serous Tubo-ovarian Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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