Fabrication of Polycaprolactone (PCL)‐Based Electrospun Membrane for Biomedical Applications Using a New Green Solvent System

The widespread use of polycaprolactone (PCL) in electrospun scaffolds for biomedical applications is often hindered by the reliance on toxic halogenated solvents such as chloroform and dichloromethane. In this study, an innovative green solvent system based on acetone and dimethyl carbonate (DMC) is proposed for the electrospinning of PCL, aiming to reduce environmental and health risks while preserving fiber quality for biomedical applications. The acetone: DMC mixture was optimized for solubility, volatility, and electrospinnability to produce bead‐free, uniform nanofibers with morphological tunability. Physicochemical properties, including mechanical properties, percentage of swelling, degradation, and Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) analysis, were conducted on the electrospun membranes. Initial in vitro experiments confirm the biocompatibility of the resultant membranes, supporting their application in tissue engineering and drug delivery. This green solvent method offers a sustainable and safer approach for electrospinning PCL, without compromising its functional properties.