Figure 3 from HBV-Specific TCR–T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regimen for Recurrent HBV-Related HCC after Liver Transplantation

Q: What type of study is this?

This is a Quantitative Study study.

Qiang Zhao; Jinbo Huang; Weixin Luo; Haidong Tan; Regina Wan Ju Wong; Zhiying Liu; Meiting Qin; Jiahao Li; Sarene Koh; Lu‐En Wai; Tingting Wang; Jia Dan; Zhiyong Guo; Xiaoshun He

doi:10.1158/1078-0432.30125587

September 15, 2025Open Access

Figure 3 from HBV-Specific TCR–T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regimen for Recurrent HBV-Related HCC after Liver Transplantation

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Key Points

HBV-specific TCR-T cell therapy improved liver injury markers ALT and AST over time, enhancing recovery.
Notable changes in liver injury markers were observed at various time points during TCR-T cell treatment.
The combination of mRNA electroporation and lentiviral transduction enabled effective HBV-specific TCR-T cell infusion.
These findings highlight the potential of new therapies for managing recurrent HBV-related HCC post-transplantation.

Implication

Observational analysis shows treatment impacts liver injury markers in recurrent HBV-related HCC, suggesting therapeutic potential.

Abstract

A–F, Changes in liver injury markers (ALT and AST) at different time points during HBV–TCR–T cell treatment. The shaded square area in the graph represents the reference range for each marker. The black dashed line indicates the time points of mRNA–HBV–TCR–T cell infusion, and the red dashed line indicates the time points of lenti-HBV–TCR–T cell infusion.

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Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa58941 https://doi.org/10.1158/1078-0432.30125587

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Figure 3 from HBV-Specific TCR–T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regimen for Recurrent HBV-Related HCC after Liver Transplantation

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure 3 from HBV-Specific TCR–T Cell Therapy Combining mRNA Electroporation and Lentiviral Transduction: Treatment Regimen for Recurrent HBV-Related HCC after Liver Transplantation

Key Points

Implication

Abstract

Discussion

Cite This Study

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