Ene-reductase demonstrates a 95% yield in cross-coupling of aromatic compounds with diethyl bromomalonate, indicating new reaction pathways.
Visible light activates "ene"-reductase to catalyze the cross-coupling reaction between aromatic compounds and diethyl bromomalonate. In this transformation, NADPH and its regeneration system are abandoned, and the cofactor FMNox is employed to directly initiate the reaction. This reaction exhibits excellent substrate compatibility, with a maximum catalytic yield of 95%. It expands the range of radical precursors for "ene"-reductase-catalyzed reactions and diversifies the reaction types.
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Zheng et al. (2025) studied this question.
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