September 16, 2025Open Access

Molecular rewiring of human induced pluripotent stem cell-derived cardiomyocytes during metabolic maturation

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This research shows metabolic maturation alters the transcriptional network in hiPSC-CMs, highlighting potential cardiotoxicity mechanisms.

We found significant rewiring of the transcriptional network in hiPSC-CMs during metabolic maturation, enhancing their functionality.
Analysis revealed mTORC1 signaling suppression as a critical factor in the maturation process of hiPSC-CMs.
Utilizing a multiomics approach enabled a comprehensive understanding of epigenome and proteomics changes linked to maturation.
Responses to Doxorubicin treatment indicated alterations in gene regulation related to extracellular matrix and contractile machinery.

Hamledari et al. (2025) studied this question.

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This research shows metabolic maturation alters the transcriptional network in hiPSC-CMs, highlighting potential cardiotoxicity mechanisms.