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This is a Quantitative Study study.

September 16, 2025Open Access

A genomic-led strategy to anticipate drug safety effects

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Our analysis revealed that about 40% of predicted adverse drug reactions were corroborated by FDA data.
The genetics-led strategy included insights from 1,449 human phenotypes and mapped to 16,915 genes.
Mendelian randomization was used across extensive genetic datasets from multiple cohorts to systematically identify safety risks.
Identified immune-related pathways showed significant associations with adverse drug reactions, emphasizing the relevance for drug development.

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Implication

This research demonstrates a genetics-led approach to predict adverse drug reactions using large-scale genetic datasets, highlighting implications for drug safety.

Cite This Study

Ferolito et al. (2025) studied this question.

synapsesocial.com/papers/68d4538f31b076d99fa58fc0 https://doi.org/10.1101/2025.09.11.25335448

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Implication

This research demonstrates a genetics-led approach to predict adverse drug reactions using large-scale genetic datasets, highlighting implications for drug safety.

A genomic-led strategy to anticipate drug safety effects

Key Points

Discussion

Implication

Cite This Study

A genomic-led strategy to anticipate drug safety effects

Key Points

Discussion

Implication

Cite This Study