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September 16, 2025Open Access

Bayesian Learning to Reduce Cardiac Risk for Locally Advanced NSCLC Patients Based on Personalized Radiotherapy Prescription

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Authors

RLRuitao LinMCMei ChenXZXiaodong Zhang

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Overview

Prospective trial shows reduced cardiovascular events in locally advanced NSCLC patients using personalized radiation treatment, suggesting improved heart safety.

Key Points

  • PART was associated with a lower incidence of hs-cTnT elevation after radiation treatment, enhancing cardiac safety.
  • Patients in the personalized adaptive radiation treatment cohort demonstrated a significantly lower hs-cTnT elevation rate of 9.7%.
  • The study developed a Bayesian model incorporating heart dose constraints to evaluate cardiovascular risks in radiation therapy.
  • Clinical implementation of the PART model proved feasible and generated reasonable heart dose constraints for better patient outcomes.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68d4539531b076d99fa591cehttps://doi.org/10.1101/2025.09.15.25335723
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