Combination of Mini Sarcopenia Risk Assessment questionnaire with calf circumference measurement for sarcopenia screening in older adults

This prospective study evaluates the performance of the Mini Sarcopenia Risk Assessment (MSRA)-5 questionnaire combined with calf circumference (CC) for sarcopenia screening in community-dwelling older adults. Community-dwelling older adults (≥60 years old) of Wanzhou District, Chongqing between February and April 2024 were recruited. The older adults were screened and diagnosed for sarcopenia using the MSRA-5 questionnaire combined with CC, and the gold standard diagnostic criteria for sarcopenia proposed by the Asian Working Group for Sarcopenia in 2019. The accuracy of this screening method in screening sarcopenia in community-dwelling older adults was evaluated using indicators such as sensitivity, specificity, receiver operating characteristic curve, Youden Index (YI), likelihood ratio, predictive values, and Kappa coefficient. Among 202 community-dwelling older adults, a total of 33 cases of sarcopenia were identified according to the gold standard, resulting in a detection rate of 16.4%. There were 19 male and 14 female participants included in the study. Screening was performed using the MSRA-5 questionnaire combined with CC, with a sensitivity of 96.97% and a specificity of 82.25%. The area under the receiver operating characteristic curve is 0.936 (95% CI: 0.903-0.968), and the YI is maximal at a cutoff total score of 60 points (YI = 0.792). The positive and negative likelihood ratios were 5.46 and 0.037, respectively. The positive predictive value was 51.61%, negative predictive value was 99.29%, and the Kappa coefficient was 0.587. MSRA-5 questionnaire combined with CC has good screening value for sarcopenia in older adults.