Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 16, 2025

Impact of CYP3A5 Gene Polymorphisms on Tacrolimus Pharmacokinetics and Renal Allograft Rejection in Kidney Transplant Recipients: A Meta-Analysis Across Ethnic Populations

View Full Paper
Ask AI
Bookmark
Share

Authors

AKAbdul Rehman KhanSZSyed ZaidiSHShafaq Hassan

Discussion

Loading...

Member takes

Overview

Meta-analysis reveals CYP3A5 expressers require higher tacrolimus doses and show varied rejection risk across ethnic populations.

Key Points

  • CYP3A5 expressers had significantly lower tacrolimus Co/D ratios, indicating faster metabolism and higher dose needs.
  • Ethnicity analysis showed stronger effects of polymorphisms in Asians (SMD: -1.35 to -1.50) compared to Europeans (SMD: -0.37 to -1.05).
  • Overall rejection risk was not significantly higher for expressers, but Asian populations showed a notable association (OR: 1.56, p = 0.0061).
  • Findings suggest that genotype-guided dosing of tacrolimus could enhance kidney transplant outcomes.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68d453a431b076d99fa59a10https://doi.org/10.21203/rs.3.rs-7490941/v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>CYP3A5</i> and <i>CYP3A4</i> , but not <i>ABCB1</i> Polymorphisms Affect Tacrolimus Dose-Adjusted Trough Concentrations in Kidney Transplant Recipients2014 · 60 citations
  2. 2Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients2006 · 117 citations
  3. 3Clinical Impact of the CYP3A5 6986A>G Allelic Variant on Kidney Transplantation Outcomes2016 · 24 citations