A Randomized Clinical Trial Comparing Post-bleaching Hypersensitivity Using Two Desensitizing Agents

Background Due to its ease of use and quick turnaround times, dental bleaching has grown to be one of the most popular aesthetic procedures. But regrettably, it has the bothersome consequence of dental hypersensitivity. The purpose of this clinical study was to assess the effectiveness of a desensitizing agent used during in-office bleaching with 35% hydrogen peroxide. Methods This randomized, double-blind, parallel-group clinical trial (registered at CTRI/2019/05/019123 on 22nd May 2019) included 45 participants randomly allocated into three equal groups ( n = 15) using a computer-generated sequence and opaque, sealed envelopes. Group I received Bioenamel (Prevest Denpro, India), Group II received GC Tooth Mousse (GC Corporation, Japan), and Group III received a placebo (Glycerine Liquid, Scortis Health Care). All interventions were applied post-bleaching. The primary outcome was hypersensitivity measured using a Visual Analogue Scale (VAS) immediately, daily for 7 days, and at 1 month. Data were analyzed using the Kruskal–Wallis test. Results All participants reported no baseline sensitivity prior to bleaching. Immediately after bleaching, all groups exhibited a significant increase in hypersensitivity ( p < .001). Among them, the Bioenamel group showed the lowest median VAS scores, followed by the GC Tooth Mousse group, while the placebo group demonstrated the highest sensitivity levels. A statistically significant difference in hypersensitivity was observed between groups at all evaluation intervals (immediate, 24 hours, and 1 week; p < .05), with Bioenamel consistently providing superior relief. By the end of one week and at one-month follow-up, all groups reported no sensitivity. Conclusion Bioenamel (Prevest Denpro) was the most effective at reducing post-bleaching hypersensitivity as compared to GC Tooth Mousse and placebo. Trial Registration CTRI/2019/05/019123