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Tetramethylpyrazine Protects Against Depression-Like Behaviors through CREB/CRTC1 Signaling Pathway in a Depression Mouse Model

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This animal study demonstrates that tetramethylpyrazine improves depression symptoms in mice, indicating a key role of CREB and CRTC1 pathways.

Tetramethylpyrazine significantly reduced depression-like behaviors in mice, improving overall neuronal health.
Treatment with 20 mg/kg of TMP notably elevated levels of serotonin, dopamine, and norepinephrine in the brain.
TMP administration induced expression of CREB, CRTC1, and BDNF, crucial factors for neuroprotection in depression.
The findings support the potential use of TMP derived from Ligusticum wallichii in clinical depression therapies.

Zhang et al. (2025) studied this question.

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This animal study demonstrates that tetramethylpyrazine improves depression symptoms in mice, indicating a key role of CREB and CRTC1 pathways.