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September 16, 2025European PsychiatryOpen Access

Findings from RCT’s on virtual reality-based interventions for auditory hallucinations and paranoia

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Authors

LGLouise Birkedal GlenthøjMNM. Nordentoft

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Overview

Randomized trials assessed efficacy of virtual reality therapies for auditory hallucinations and paranoia in schizophrenia.

Key Points

  • Challenge-VRT significantly reduced auditory hallucinations in individuals with schizophrenia spectrum disorders.
  • Primary outcomes indicated a reduction in symptom severity measured by PSYRATS in the Challenge trial.
  • VR-CBT did not show superior results compared to standard CBT for treating paranoia in the Face Your Fears trial.
  • Future research should examine factors influencing treatment effectiveness and personalize interventions.

Cite This Study

Glenthøj et al. (2025) studied this question.

synapsesocial.com/papers/68d454cb31b076d99fa5a309https://doi.org/10.1192/j.eurpsy.2025.55
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Virtual reality-assisted therapy targeting persistent auditory verbal hallucinations in patients diagnosed with schizophrenia spectrum disorders: the Challenge single-blind, randomized clinical trial2024 · 8 citations
  2. 2Virtual Reality for the Treatment of Auditory Hallucinations in Schizophrenia Spectrum Disorders: a Systematic Review and Meta-Analysis.2026
  3. 3Patient perspectives on modified virtual reality-assisted therapy for persistent auditory verbal hallucinations: A qualitative substudy of the CHALLENGE randomized clinical trial2026 · 1 citations
  4. 4Virtual reality-based versus standard cognitive behavioral therapy for paranoia in schizophrenia spectrum disorders: a randomized controlled trial2025
  5. 5Effectiveness and efficiency of Virtual Reality cognitive behavioural therapy for paranoid delusions - results from a randomized clinical trial2025