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September 16, 2025European PsychiatryOpen Access

Maternal depression around pregnancy and risk of mental disorder among offspring: a population-based cohort study with sibling comparison

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Authors

ANAlicia NevrianaDLDonghao Lu

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Overview

Population-based cohort study identifies maternal depression timing affects offspring mental health, suggesting shared familial factors.

Key Points

  • Maternal depression is linked to a higher risk of mental disorders in offspring during different pregnancy periods, indicating significant impact.
  • Hazard ratios revealed a stronger association for maternal depression one year before conception (HR 1.90) compared to subsequent periods.
  • A sibling comparison showed attenuated associations, highlighting the role of familial genetic and environmental factors in mental health outcomes.
  • Findings suggest that while maternal depression risks are significant, shared familial factors may diminish direct associations in siblings.

Cite This Study

Nevriana et al. (2025) studied this question.

synapsesocial.com/papers/68d454cb31b076d99fa5a331https://doi.org/10.1192/j.eurpsy.2025.360
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal psychiatric disorders before, during, and after pregnancy: a national cohort study in Sweden2025 · 3 citations
  2. 2Parental Mental Disorders and Offspring Mortality up to Middle Age2025 · 2 citations
  3. 3Timing of Exposure to Parental Depression From Pregnancy to Young Adulthood and Mental Health in Adult Offspring2026 · 2 citations
  4. 4Maternal perinatal depressive disorders and the risk of attention deficit and hyperactivity disorder in offspring: A retrospective cohort study using linked data2025
  5. 5Associations of mental disorders with maternal health outcomes2025 · 5 citations