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September 16, 2025European PsychiatryOpen Access

Precision Medicine in the treatment of alcohol dependence – the role of gender

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Authors

HWHeinz WalterMediWiSe (United Kingdom)

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Implication

Observational analysis demonstrates the role of gender in alcohol dependence, suggesting tailored approaches for anticraving medications.

Key Points

  • Precision medicine indicates that gender affects responses to anticraving drugs in alcohol dependence.
  • Genetic findings show efficacy of treatments like ondansetron only in specific subgroups, such as Lesch type 3 female patients.
  • A need exists for more homogeneous subgroups to improve treatment outcomes in alcohol dependence trials.
  • Psychosocial and biological conditions may offer insights into tailored approaches for alcohol dependence treatments.

Cite This Study

Heinz Walter (2025) studied this question.

synapsesocial.com/papers/68d454cb31b076d99fa5a423https://doi.org/10.1192/j.eurpsy.2025.123
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-dose ondansetron: A candidate prospective precision medicine to treat alcohol use disorder endophenotypes2024 · 9 citations
  2. 2Excessive Alcohol Consumption, Alcohol Use Disorder and Women2025
  3. 3Gender- and sex-sensitive psychopharmacotherapy of alcohol use disorder: a systematic review and meta-analysis protocol2025 · 1 citations
  4. 4Effectiveness of Alcohol Use Disorder Pharmacotherapies by Sex: Systematic Review and Meta‐Analysis2026
  5. 5An unsupervised machine learning analysis of biopsychosocial characteristics and treatment outcome of alcohol use disorder2026