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September 16, 2025European PsychiatryOpen Access

The Role of Mood Stabilizers and Antipsychotics in the Treatment of Borderline Personality Disorder

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Non-systematic review evaluates the efficacy of mood stabilizers and antipsychotics in BPD treatment, suggesting nuanced applications.

Mood stabilizers show the highest efficacy in improving individual symptoms of borderline personality disorder.
Antipsychotics also improve symptoms but show a lower effect size compared to mood stabilizers.
Pharmacotherapy can target core symptoms of BPD, though the evidence for overall effectiveness is of very low certainty.
No significant difference exists between pharmacotherapy and placebo regarding dropout rates in borderline personality disorder patients.

Barbosa et al. (2025) studied this question.

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