C(sp²)–C(sp²) and C(sp²)–C(sp³) Nickel-Catalyzed Kumada–Corriu and Buchwald–Hartwig Cross-Coupling of Aryl Sulfamates Enabled by Sterically-Demanding, Electron-Rich IPr*OMe N-Heterocyclic Carbenes

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This is a Quantitative Study study.

Marlena Kardela; Michal Szostak; Elwira Bisz

doi:10.1039/d5cy00685f

January 1, 2025Catalysis Science & Technology

C(sp²)–C(sp²) and C(sp²)–C(sp³) Nickel-Catalyzed Kumada–Corriu and Buchwald–Hartwig Cross-Coupling of Aryl Sulfamates Enabled by Sterically-Demanding, Electron-Rich IPr*OMe N-Heterocyclic Carbenes

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Key Points

Nickel-catalyzed cross-coupling reactions achieved better efficiency, improving yields of aryl sulfamates and providing a cost-effective method.
The use of sterically-demanding, electron-rich IPr*OMe N-heterocyclic carbenes increased the activity of nickel catalysts in these coupling processes.
These reactions allow the formation of C(sp²)–C(sp²) and C(sp²)–C(sp³) bonds, contributing to significant advancements in organic synthesis.
The findings indicate a promising strategy for utilizing inexpensive nickel catalysts, with implications for wider applications in organic chemistry.

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Implication

Analysis reveals enhanced efficiency in nickel-catalyzed Kumada–Corriu and Buchwald–Hartwig reactions, suggesting better yields for aryl sulfamates.

Abstract

Nickel-catalyzed cross-coupling reactions are among the most powerful tools in organic synthesis owing to the low cost, natural abundance and high activity of versatile nickel catalysts. However, there is a...

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Kardela et al. (2025) studied this question.

synapsesocial.com/papers/68d4565431b076d99fa5b0c5 https://doi.org/10.1039/d5cy00685f

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C(sp²)–C(sp²) and C(sp²)–C(sp³) Nickel-Catalyzed Kumada–Corriu and Buchwald–Hartwig Cross-Coupling of Aryl Sulfamates Enabled by Sterically-Demanding, Electron-Rich IPr*OMe N-Heterocyclic Carbenes

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C(sp²)–C(sp²) and C(sp²)–C(sp³) Nickel-Catalyzed Kumada–Corriu and Buchwald–Hartwig Cross-Coupling of Aryl Sulfamates Enabled by Sterically-Demanding, Electron-Rich IPr*OMe N-Heterocyclic Carbenes

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