Electrochemical study demonstrates selective cross-electrophile coupling using organic halides and cyclosulfonium salts, highlighting a sustainable platform for complex molecule synthesis.
An electrochemical nickel-catalyzed cross-electrophile coupling reaction of organic halides with cyclosulfonium salts to construct C(sp3)–C(sp3)/C(sp2) bonds is reported. This highly selective synthetic approach demonstrates significant practical utility, as evidenced by its broad substrate scope encompassing C(sp3)–/C(sp2)–iodides, while maintaining excellent functional group tolerance, particularly challenging late-stage functionalization applications. Moreover, density functional theory (DFT) calculations are employed to systematically evaluate the Gibbs free energy profile of key intermediates along the proposed nickel-catalyzed reaction pathway, thereby providing robust theoretical support for the mechanistic feasibility of the transformation.
No takes yet. Share an insight, caveat, or question.
Yong-fei et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: